English | 2022 | ISBN: 1119671345 | 355 pages | True PDF EPUB | 18.76 MB
GENOME EDITING IN DRUG DISCOVERYA practical guide for researchers and professionals applying genome editing techniques to drug discovery
InGenome Editing in Drug Discovery,a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.
The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented.
Offering practical suggestions for practitioners and academicians involved in drug discovery,Genome Editing in Drug Discoveryis a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include:
A thorough introduction to the applications of CRISPRi and CRISPRa in drug discoveryComprehensive explorations of genome-editing applications in stem cell engineering and regenerative medicinePractical discussions of the safety aspects of genome editing with respect to immunogenicity and the specificity of CRISPR-Cas9 gene editingIn-depth examinations of critical socio-economic and bioethical challenges in the CRISPR-Cas9 patent landscape
Perfect for academic researchers and professionals in the biotech and pharmaceutical industries,Genome Editing in Drug Discoverywill also earn a place in the libraries of medicinal chemists, biochemists, and molecular biologists.
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